RsmV is a small non-coding RNA (sRNA) that has been found first in Pseudomonas aeruginosa genomes.[1] It is a member of the Rsm family of sRNAs (RsmZ, RsmY, RsmX, and RsmW), which are known to play a role in regulating gene expression. RsmV differs from other Rsm sRNAs by being GacA[2]-independent and able of binding RsmA[1] and RsmF[3] proteins.[4]
Phylogenetic distribution of RsmV sRNA can be divided in three subgroups of rsmV alleles:
- rsmVa, exclusively present in P. aeruginosa chromosomes,
- rsmVb, characteristic of strains from P. chlororaphis clades, and
- rsmVc, found in strains from P. fluorescens and P. protegens clades, and other non-clustered isolates.[5]
RsmV is approximately 100 nucleotides in length.
See also
editReferences
edit- ^ a b "Pseudomonas Genome DB".
- ^ Brencic, Anja; McFarland, Kirsty A.; McManus, Heather R.; Castang, Sandra; Mogno, Ilaria; Dove, Simon L.; Lory, Stephen (2009). "The GacS/GacA signal transduction system of Pseudomonas aeruginosa acts exclusively through its control over the transcription of the RsmY and RsmZ regulatory small RNAs". Molecular Microbiology. 73 (3): 434–445. doi:10.1111/j.1365-2958.2009.06782.x. ISSN 1365-2958. PMC 2761719. PMID 19602144.
- ^ "UniProt".
- ^ Janssen, Kayley H.; Diaz, Manisha R.; Gode, Cindy J.; Wolfgang, Matthew C.; Yahr, Timothy L. (2018-07-25). "RsmV, a Small Noncoding Regulatory RNA in Pseudomonas aeruginosa That Sequesters RsmA and RsmF from Target mRNAs". Journal of Bacteriology. 200 (16): 10.1128/jb.00277–18. doi:10.1128/jb.00277-18. PMC 6060366. PMID 29866805.
- ^ Gallegos, María Trinidad; Garavaglia, Matías; Valverde, Claudio (2024). "Small Regulatory RNAs of the Rsm Clan in Pseudomonas". Molecular Microbiology. 122 (4): 563–582. doi:10.1111/mmi.15313. ISSN 1365-2958.