Niles Pierce

Niles A. Pierce is an American mathematician, bioengineer, and professor at the California Institute of Technology. He is a leading researcher in the fields of molecular programming and dynamic nucleic acid nanotechnology. His research is focused on kinetically controlled DNA and RNA self-assembly. Pierce is working on applications in bioimaging.

Pierce graduated as the Valedictorian ^[1] of the Princeton University class of 1993 with a BSE in Mechanical & Aerospace Engineering. He then attended Oxford University as a Rhodes Scholar, an achievement repeated nine years later by his sister Lillian Pierce.^[2] He completed a DPhil in Applied Mathematics in 1997. He joined the faculty of the California Institute of Technology in 2000.

Works

Choi, Harry M. T.; Beck, Victor A.; Pierce, Niles A. (8 April 2014). "Next-Generation in Situ Hybridization Chain Reaction: Higher Gain, Lower Cost, Greater Durability". ACS Nano. 8 (5). American Chemical Society (ACS): 4284–4294. doi:10.1021/nn405717p. ISSN 1936-0851. PMC 4046802. PMID 24712299.
Hochrein, Lisa M.; Schwarzkopf, Maayan; Shahgholi, Mona; Yin, Peng; Pierce, Niles A. (12 November 2013). "Conditional Dicer Substrate Formation via Shape and Sequence Transduction with Small Conditional RNAs". Journal of the American Chemical Society. 135 (46). American Chemical Society (ACS): 17322–17330. doi:10.1021/ja404676x. ISSN 0002-7863. PMC 3842090. PMID 24219616.
Zadeh, Joseph N.; Wolfe, Brian R.; Pierce, Niles A. (17 August 2010). "Nucleic acid sequence design via efficient ensemble defect optimization". Journal of Computational Chemistry. 32 (3). Wiley: 439–452. doi:10.1002/jcc.21633. ISSN 0192-8651. PMID 20717905. S2CID 1803200.
Zadeh, Joseph N.; Steenberg, Conrad D.; Bois, Justin S.; Wolfe, Brian R.; Pierce, Marshall B.; Khan, Asif R.; Dirks, Robert M.; Pierce, Niles A. (17 November 2010). "NUPACK: Analysis and design of nucleic acid systems". Journal of Computational Chemistry. 32 (1). Wiley: 170–173. doi:10.1002/jcc.21596. ISSN 0192-8651. PMID 20645303. S2CID 33709556.
Choi, Harry M T; Chang, Joann Y; Trinh, Le A; Padilla, Jennifer E; Fraser, Scott E; Pierce, Niles A (31 October 2010). "Programmable in situ amplification for multiplexed imaging of mRNA expression". Nature Biotechnology. 28 (11). Springer Science and Business Media LLC: 1208–1212. doi:10.1038/nbt.1692. ISSN 1087-0156. PMC 3058322. PMID 21037591.
Yin, Peng; Choi, Harry M. T.; Calvert, Colby R.; Pierce, Niles A. (2008). "Programming biomolecular self-assembly pathways". Nature. 451 (7176). Springer Science and Business Media LLC: 318–322. Bibcode:2008Natur.451..318Y. doi:10.1038/nature06451. ISSN 0028-0836. PMID 18202654. S2CID 4354536.
Dirks, Robert M.; Bois, Justin S.; Schaeffer, Joseph M.; Winfree, Erik; Pierce, Niles A. (2007). "Thermodynamic Analysis of Interacting Nucleic Acid Strands". SIAM Review. 49 (1). Society for Industrial & Applied Mathematics (SIAM): 65–88. Bibcode:2007SIAMR..49...65D. doi:10.1137/060651100. ISSN 0036-1445.
Dirks, Robert M.; Pierce, Niles A. (18 October 2004). "Triggered amplification by hybridization chain reaction". Proceedings of the National Academy of Sciences. 101 (43): 15275–15278. doi:10.1073/pnas.0407024101. ISSN 0027-8424. PMC 524468. PMID 15492210.
Shin, Jong-Shik; Pierce, Niles A. (17 August 2004). "A Synthetic DNA Walker for Molecular Transport". Journal of the American Chemical Society. 126 (35). American Chemical Society (ACS): 10834–10835. doi:10.1021/ja047543j. ISSN 0002-7863. PMID 15339155.

Resources

NUPACK is a growing software suite for the analysis and design of nucleic acid structures, devices, and systems.
Molecular Technologies develops and supports programmable molecular technologies for reading out and regulating the state of endogenous biological circuitry.

Startup Company

Molecular Instruments, Inc. designs and synthesizes molecular kits for multiplexed quantitative bioimaging in academic research, drug development, and clinical diagnostics.

References

^ "COMMENCEMENT; Princeton President Addresses Graduates". The New York Times. 9 June 1993.
^ Stevens, Ruth (June 3, 2002), "Selection as valedictorian a family affair for the Pierces", Princeton Weekly Bulletin, 92 (27)

External links

"People - Pierce Lab". Pierce Lab. Retrieved 22 November 2022.

[1] "COMMENCEMENT; Princeton President Addresses Graduates". The New York Times. 9 June 1993.

[2] Stevens, Ruth (June 3, 2002), "Selection as valedictorian a family affair for the Pierces", Princeton Weekly Bulletin, 92 (27)

[1]