3,4-Methylenedioxyphentermine

3,4-Methylenedioxyphentermine (MDPH) is a lesser-known drug of the amphetamine family. MDPH was first synthesized by Alexander Shulgin. Very little data exists about the pharmacological properties, metabolism, and toxicity of MDPH.

3,4-Methylenedioxyphentermine

Names
Preferred IUPAC name 1-(2H-1,3-Benzodioxol-5-yl)-2-methylpropan-2-amine
Other names MDP; MDPH; 3,4-Methylenedioxyphentermine; 3,4-Methylenedioxy-alpha,alpha-dimethyl-1-ethane
Identifiers
CAS Number	39235-63-7 Y
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL126226
ChemSpider	15204207 Y
PubChem CID	13020598
UNII	WF9K2PM8J8
CompTox Dashboard (EPA)	DTXSID90515395
InChI InChI=1S/C11H15NO2/c1-11(2,12)6-8-3-4-9-10(5-8)14-7-13-9/h3-5H,6-7,12H2,1-2H3 N Key: OIZBHKBNZXRXSM-UHFFFAOYSA-N N InChI=1/C11H15NO2/c1-11(2,12)6-8-3-4-9-10(5-8)14-7-13-9/h3-5H,6-7,12H2,1-2H3 Key: OIZBHKBNZXRXSM-UHFFFAOYAY
SMILES NC(C)(C)CC1=CC(OCO2)=C2C=C1
Properties
Chemical formula	C11H15NO2
Molar mass	193.246 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

In his book PiHKAL (Phenethylamines i Have Known And Loved), the dosage range is listed as 160–240 mg, and the duration as 3–5 hours.^[1] MDPH's effects are very similar to those of MDA: they both are smooth and "stoning," and do not cause any visuals. They also alter dreams and dream patterns. Shulgin describes MDPH as a promoter; it promotes the effects of other drugs, similarly to 2C-D.

The N-methyl derivative, 3,4-methylenedioxy-N-methylphentermine (MDMPH), has been described by Shulgin as lacking MDMA-like effects.^[2] Accordingly, MDMPH, as well as MDPH, were found to be inactive as serotonin releasing agents in vitro.^[2][3]