Summary
The penetration of ampicillin into middle ear effusions after oral administration of 800 mg bacampicillin to patients with acute otitis media was studied and compared with the serum levels. One hour after administration a mean (±SEM) concentration of 2.4±0.4 µg/ml ampicillin was found in the effusions and the mean serum level was 7.7±0.8 µg/ml. After twelve hours a mean concentration of 0.6±0.2 µg/ml was found in the middle ear effusions and 0.1±0.03 µg/ml in the serum. The high concentration of ampicillin in middle ear effusions after twelve hours suggests that a twice daily dosage of bacampicillin should be given in acute otitis media.
Zusammenfassung
Die Penetration von Ampicillin in das Mittelohrsekret nach oraler Gabe von 800 mg Bacampicillin unter vergleichender Berücksichtigung der Serumspiegel wurde bei Patienten mit akuter Otitis media untersucht. Eine Stunde nach Verabreichung des Medikaments wurde in den Sekreten eine mittlere Konzentration von 2,4±0,4 µg/ml Ampicillin gefunden; der mittlere Serumspiegel betrug 7,7±0,8 µg/ml. Nach zwölf Studen fand sich eine mittlere Konzentration von 0,6±0,2 µg/ml in den Mittelohrsekreten und von 0,1±0,03 µg/ml im Serum. Aus der hohen Konzentration von Ampicillin in Mittelohrsekreten nach zwölf Stunden kann eine zweimal tägliche Dosierung von Bacampicillin bei Otitis media abgeleitet werden.
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Virtanen, S., Lahikainen, E.A. Ampicillin concentrations in middle ear effusions in acute otitis media after administration of bacampicillin. Infection 7 (Suppl 5), S472–S474 (1979). https://doi.org/10.1007/BF01659775
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DOI: https://doi.org/10.1007/BF01659775