MAX

MAX
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1AN2, 1HLO, 1NKP, 1NLW, 1R05
Dynodwyr
Cyfenwau	MAX, bHLHd4, max, MYC associated factor X
Dynodwyr allanol	OMIM: 154950 HomoloGene: 1786 GeneCards: MAX
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• sequence-specific DNA binding; • protein dimerization activity; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0001105 transcription coactivator activity; • GO:0001104 transcription coregulator activity; • GO:0000983 RNA polymerase II general transcription initiation factor activity; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001948, GO:0016582 protein binding; • DNA binding; • protein homodimerization activity; • E-box binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0032403 protein-containing complex binding; • protein heterodimerization activity;
Cydrannau o'r gell	• PML body; • cell projection; • dendrite; • cnewyllyn cell; • nucleoplasm; • cytoplasm; • protein-DNA complex; • MLL1 complex; • RNA polymerase II transcription regulator complex;
Prosesau biolegol	• neuron apoptotic process; • GO:0009373 regulation of transcription, DNA-templated; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • cellular response to starvation; • transcription by RNA polymerase II; • negative regulation of gene expression; • transcription, DNA-templated; • response to insulin; • cellular response to peptide hormone stimulus; • retina development in camera-type eye; • response to axon injury; • response to organonitrogen compound; • GO:1901227 negative regulation of transcription by RNA polymerase II; • negative regulation of G0 to G1 transition; • G1/S transition of mitotic cell cycle; • GO:0034622 protein-containing complex assembly; • positive regulation of nucleic acid-templated transcription; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologau
	4149
	n/a
	ENSG00000125952
	n/a
	P61244; Q8TAX8
	n/a
NM_001271068; NM_001271069; NM_002382; NM_145112; NM_145113;
	NM_145114; NM_145116; NM_197957; NM_001320415
	n/a
NP_001257997; NP_001257998; NP_001307344; NP_002373; NP_660087;
	NP_660088; NP_660089; NP_932061; NP_002373.3; NP_660087.1; NP_660088.1; NP_001307344.1
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MAX yw MAX a elwir hefyd yn MYC associated factor X (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 14, band 14q23.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MAX.

bHLHd4

Llyfryddiaeth

"Biophysical characterization of the b-HLH-LZ of ΔMax, an alternatively spliced isoform of Max found in tumor cells: Towards the validation of a tumor suppressor role for the Max homodimers. ". PLoS One. 2017. PMID 28350847.
"MAX is an epigenetic sensor of 5-carboxylcytosine and is altered in multiple myeloma. ". Nucleic Acids Res. 2017. PMID 27903915.
"Social stress in adolescents induces depression and brain-region-specific modulation of the transcription factor MAX. ". Transl Psychiatry. 2016. PMID 27727240.
"Complex MAX Rearrangement in a Family With Malignant Pheochromocytoma, Renal Oncocytoma, and Erythrocytosis. ". J Clin Endocrinol Metab. 2016. PMID 26670126.
"Functional and in silico assessment of MAX variants of unknown significance.". J Mol Med (Berl). 2015. PMID 26070438.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] MAX - Cronfa NCBI

[2]