IL4

IL4
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1BBN, 1BCN, 1CYL, 1HIJ, 1HIK, 1HZI, 1IAR, 1ITI, 1ITL, 1ITM, 1RCB, 2B8U, 2B8X, 2B8Y, 2B8Z, 2B90, 2B91, 2CYK, 2D48, 2INT, 3BPL, 3BPN, 3QB7, 4YDY, 5FHX
Dynodwyr
Cyfenwau	IL4, Interleukin 4, IL-4
Dynodwyr allanol	HomoloGene: 491 GeneCards: IL4
Ontoleg y genyn
Gweithrediad moleciwlaidd	• interleukin-4 receptor binding; • GO:0001948, GO:0016582 protein binding; • growth factor activity; • GO:0005145 cytokine receptor binding; • cytokine activity;
Cydrannau o'r gell	• extracellular region; • extracellular space;
Prosesau biolegol	• positive regulation of T cell differentiation; • dendritic cell differentiation; • negative regulation of endothelial cell apoptotic process; • negative regulation of complement-dependent cytotoxicity; • regulation of phosphorylation; • negative regulation of apoptotic process; • myeloid dendritic cell differentiation; • type 2 immune response; • B cell activation; • positive regulation of interleukin-13 production; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response; • B cell differentiation; • T-helper 2 cell cytokine production; • regulation of isotype switching; • GO:0045996 negative regulation of transcription, DNA-templated; • negative regulation of epithelial cell migration; • regulation of signaling receptor activity; • cholesterol metabolic process; • positive regulation of B cell proliferation; • positive regulation of T cell proliferation; • T cell activation; • positive regulation of MHC class II biosynthetic process; • negative regulation of osteoclast differentiation; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • positive regulation of isotype switching to IgE isotypes; • positive regulation of isotype switching to IgG isotypes; • regulation of immune response; • cytokine-mediated signaling pathway; • GO:1901313 positive regulation of gene expression; • positive regulation of macroautophagy; • positive regulation of tyrosine phosphorylation of STAT protein; • activation of Janus kinase activity; • positive regulation of receptor-mediated endocytosis; • positive regulation of cold-induced thermogenesis; • negative regulation of neuroinflammatory response; • positive regulation of amyloid-beta clearance; • neuroinflammatory response; • positive regulation of cellular respiration; • positive regulation of ATP biosynthetic process;
	Sources:Amigo / QuickGO
Orthologau
	3565
	n/a
	ENSG00000113520
	n/a
	P05112
	n/a
	NM_000589.4
	n/a
	NP_000580; NP_758858; NP_001341919
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IL4 yw IL4 a elwir hefyd yn Interleukin 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 5, band 5q31.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IL4.

BSF1
IL-4
BCGF1
BSF-1
BCGF-1

Llyfryddiaeth

"IL4 Primes the Dynamics of Breast Cancer Progression via DUSP4 Inhibition. ". Cancer Res. 2017. PMID 28400477.
"Association between interleukin-4 polymorphisms and risk of pre-eclampsia in a population of Chinese pregnant women. ". Genet Mol Res. 2017. PMID 28387873.
"Genotyping of IL-4-590 (C>T) Gene in Iraqi Asthma Patients. ". Dis Markers. 2017. PMID 28386156.
"Single nucleotide polymorphisms of interleukins associated with hepatitis C virus infection in Egypt. ". J Infect Dev Ctries. 2017. PMID 28368861.
"Interleukin 4 -590C/T (rs2243250) Polymorphism Is Associated With Increased Risk of Atopic Dermatitis: Meta-Analysis of Case-Control Studies.". Dermatitis. 2017. PMID 28169853.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] IL4 - Cronfa NCBI

[2]