FDFT1

FDFT1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1EZF, 3ASX, 3LEE, 3Q2Z, 3Q30, 3V66, 3VJ8, 3VJ9, 3VJA, 3VJB, 3VJC, 3WC9, 3WCD, 3WCF, 3WCH, 3WCI, 3WCJ, 3WCL, 3WCM, 3WEF, 3WEG, 3WEH, 3WEI, 3WEJ, 3WEK, 3WSA
Identifikatori
Aliasi	FDFT1
Vanjski ID-jevi	OMIM: 184420 MGI: 102706 HomoloGene: 3281 GeneCards: FDFT1
Lokacija gena (čovjek)
Hrom.	Hromosom 8 (čovjek)
Kraj	11,839,304 bp
Lokacija gena (miš)
Hrom.	Hromosom 14 (miš)
Kraj	63,417,027 bp
Ontologija gena
Molekularna funkcija	• aktivnost sa transferazom; • catalytic activity; • GO:0048045 transferase activity, transferring alkyl or aryl (other than methyl) groups; • farnesyl-diphosphate farnesyltransferase activity; • squalene synthase activity; • GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje iona metala;
Ćelijska komponenta	• integral component of membrane; • membrana; • intracellular membrane-bounded organelle; • Endoplazmatski retikulum; • endoplasmic reticulum membrane;
Biološki proces	• steroid metabolic process; • sterol biosynthetic process; • lipid biosynthetic process; • lipid metabolism; • cholesterol metabolic process; • Biosinteza; • isoprenoid biosynthetic process; • metabolizam; • steroid biosynthetic process; • cholesterol biosynthetic process; • ergosterol biosynthetic process; • farnesyl diphosphate metabolic process; • regulation of lipid metabolic process; • regulation of cholesterol biosynthetic process;
	Izvori:Amigo / QuickGO
Ortolozi
	2222
	14137
	ENSG00000079459; ENSG00000284967
	ENSMUSG00000021273
	P37268; Q6IAX1
	P53798
NM_001287742; NM_001287743; NM_001287744; NM_001287745; NM_001287747;
	NM_001287748; NM_001287749; NM_001287750; NM_001287751; NM_001287756; NM_004462
	NM_010191; NM_001360211
NP_001274671; NP_001274672; NP_001274673; NP_001274674; NP_001274676;
	NP_001274677; NP_001274678; NP_001274679; NP_001274680; NP_001274685; NP_004453; NP_001274671.1; NP_001274672.1; NP_004453.3
	NP_034321; NP_001347140
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Farnezil-difosfat farneziltransferaza 1 je proteinski enzim koji je kod ljudi kodiran genom FDFT1.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 417 aminokiselina, а molekulska težina 48.115 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MEFVKCLGHP	EEFYNLVRFR	IGGKRKVMPK	MDQDSLSSSL	KTCYKYLNQT
SRSFAAVIQA	LDGEMRNAVC	IFYLVLRALD	TLEDDMTISV	EKKVPLLHNF
HSFLYQPDWR	FMESKEKDRQ	VLEDFPTISL	EFRNLAEKYQ	TVIADICRRM
GIGMAEFLDK	HVTSEQEWDK	YCHYVAGLVG	IGLSRLFSAS	EFEDPLVGED
TERANSMGLF	LQKTNIIRDY	LEDQQGGREF	WPQEVWSRYV	KKLGDFAKPE
NIDLAVQCLN	ELITNALHHI	PDVITYLSRL	RNQSVFNFCA	IPQVMAIATL
AACYNNQQVF	KGAVKIRKGQ	AVTLMMDATN	MPAVKAIIYQ	YMEEIYHRIP
DSDPSSSKTR	QIISTIRTQN	LPNCQLISRS	HYSPIYLSFV	MLLAALSWQY
LTTLSQVTED	YVQTGEH

Funkcija

Ovaj gen kodira membranski povezani enzim koji se nalazi na tački grananja mevalonatnog puta. Kodirani protein je prvi specifični enzim u biosintezi holesterola, koji katalizira dimerizaciju dvije molekule farnezil difosfata u reakciji u dva koraka u obliku skvalena.

Reference

^ ^a ^b ^c ENSG00000284967 GRCh38: Ensembl release 89: ENSG00000079459, ENSG00000284967 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021273 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Farnesyl-diphosphate farnesyltransferase 1". Pristupljeno 25. 6. 2016.
^ "UniProt, P37268" (jezik: engleski). Pristupljeno 17. 9. 2021.

Dopunska literatura

Kavanagh KL, Guo K, Dunford JE, Wu X, Knapp S, Ebetino FH, Rogers MJ, Russell RG, Oppermann U (2006). "The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs". Proc. Natl. Acad. Sci. U.S.A. 103 (20): 7829–34. Bibcode:2006PNAS..103.7829K. doi:10.1073/pnas.0601643103. PMC 1472530. PMID 16684881.

[refGRCh38Ensembl-1] ENSG00000284967 GRCh38: Ensembl release 89: ENSG00000079459, ENSG00000284967 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021273 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Farnesyl-diphosphate farnesyltransferase 1". Pristupljeno 25. 6. 2016.

[UniProt-6] "UniProt, P37268" (jezik: engleski). Pristupljeno 17. 9. 2021.

[1]